Kisspeptin-10

Kisspeptin-10 is a synthetic, C-terminally amidated decapeptide in the KISS1 gene-product family. Its sequence is YNWNSFGLRF-NH2, corresponding to residues 45–54 of the 54-residue KISS1 gene product. The terminal NH2 denotes an amide rather than a free carboxyl terminus. That distinction matters when formula, mass and sequence records are compared.

The formula and average molecular weight below describe the amidated free reference structure recorded under PubChem CID 25240297. These documentary identifiers define a reference entity; none authenticates a physical sample, establishes its molecular form or reports an analytical result.

Reference identity and batch identity are separate questions. Assignment of supplied material requires batch-linked evidence.

Identity and receptor-pharmacology source: Kotani et al. 2001 · PMID 11457843

In vitro receptor pharmacology identified KISS1R, also called GPR54, as the tested receptor designation and reported binding and activation by KISS1-derived peptides in cellular preparations. In that in vitro study, the C-terminal decapeptide retained agonist potency under the assay conditions. Receptor binding, receptor activation and agonist potency are related but distinct experimental measurements, and none provides batch identification.

Preclinical antagonist pharmacology reported GnRH-neuron activity and LH pulsatility across experimental models. A preclinical mouse model reported GPR54-dependent GnRH-neuron activation, with an LH response absent in the receptor-deficient model. These designs address different questions.

Mechanism sources: Kotani et al. 2001 · PMID 11457843 · Roseweir et al. 2009 · PMID 19321788 · Messager et al. 2005 · PMID 15665093

This section describes findings in controlled research and makes no statement about use. The evidence progresses from in vitro cellular preparations through preclinical rodent models, human genetics studies, a human clinical study and a literature review. Each observation remains bounded by its molecule, model, method and endpoint; no listed publication analyses a Reborn Peptides batch.

Evidence map: PMID 11457843 · PMID 19321788 · PMID 15665093 · PMID 15665556 · PMID 15217982 · PMID 14573733 · PMID 12944565 · PMID 21632807 · PMID 22811428

Kisspeptin-10, kisspeptin 10 and KP-10 are names for the same sequence-defined molecule. The punctuation and abbreviation do not create separate compounds. “Metastin 45–54” may also identify this decapeptide because the residue range is explicit.

Kisspeptin-54, also called Metastin, is the 54-residue parent peptide. Kisspeptin-13 and Kisspeptin-14 are longer C-terminal fragments. Shared origin and overlapping sequences do not make these molecular records interchangeable with Kisspeptin-10. Each length requires its own sequence assignment, terminal-form description, identifiers, specification and batch documentation.

“Metastin 45–54” points to the C-terminal decapeptide, whereas “Metastin” without a residue range commonly denotes Kisspeptin-54. A family name cannot justify transferring evidence between peptide lengths.

Naming context: Kotani et al. 2001 · PMID 11457843 · Pinilla et al. 2012 · PMID 22811428

No fill quantity, salt form, storage condition or stability period is asserted here. Those particulars must come from the released label, applicable specification and matching batch documentation. Reference formula, average molecular weight and sequence length do not establish any of them.

For documentary review, the product designation and sequence should agree across the label and specification, while the batch code should connect the material to its COA. The analytical record should identify the tested sample, method, test date and result. Any inconsistency in that chain must be resolved before the record is assigned to the material.

An HPLC purity value is method- and batch-specific and applies only to the tested batch. It cannot be generalised to other material. Chromatography and molecular identity also answer separate analytical questions; a database identifier does not measure purity, and an HPLC result alone does not necessarily establish the complete sequence or molecular form.

Laboratories seeking Kisspeptin-10 research supply in the EU should evaluate reference identity and batch documentation separately. Published papers define investigated models and endpoints; released records define a supplied sample. Neither substitutes for the other.

Kisspeptin-10 is presented solely as research material for controlled laboratory work. The cited evidence establishes no conclusion beyond its named systems and measurements and provides no analytical certification of Reborn Peptides material.

Research use only. For laboratory research only. Not for human or veterinary use. Not intended to diagnose, treat, cure or prevent any disease. Not a medicinal product, food or cosmetic.