Epithalon for Laboratory Research

Epithalon is a synthetic linear tetrapeptide with the sequence alanine–glutamic acid–aspartic acid–glycine, abbreviated AEDG. Three peptide bonds connect its four residues. The spelling Epitalon is used in scientific literature for the same sequence-defined molecule. Sequence and reference identifiers establish the bibliographic entity against which records can be compared; they do not authenticate a received sample or predict an experimental result.

The formula and average molecular weight below describe the neutral free reference structure. They do not determine whether supplied material has the free form or another molecular form. That distinction, like identity and any analytical result, must be reconciled against the applicable label, specification and batch COA.

Identity and sequence context: Khavinson et al. 2017 · PMID 29124531

The source literature does not support one unified target claim. It reports distinct measurements in defined systems: telomerase activity and telomere length in cultured cells, transcription initiation at selected promoters in a molecular system, and AANAT, pCREB and melatonin synthesis in pinealocyte culture. These terms name experimental endpoints, not inherent properties of a supplied batch.

The 2003 fetal-fibroblast study reported telomerase activation and telomere elongation under its culture conditions. A separate 2004 fibroblast paper reported further cell divisions at the usual proliferative limit. Later work in cultured human cell lines measured telomere length, hTERT, telomerase activity and an ALT signal in some investigated lines. These studies are related by topic, but they are not interchangeable replications.

Mechanism-term sources: PMID 12937682 · PMID 15455129 · PMID 14666197 · PMID 22816096 · PMID 40908429

This section describes findings in controlled research and makes no statement about use. The evidence progresses across in vitro molecular and cell systems, biological-material identification and a preclinical ex vivo bovine model. Model, sample, method and endpoint delimit every interpretation; no listed publication analyses a Reborn Peptides batch.

Study sources: PMID 14666197 · PMID 12937682 · PMID 15455129 · PMID 22816096 · PMID 40908429 · PMID 29124531 · PMID 39788414

Epithalon and Epitalon are spelling variants for the same synthetic AEDG tetrapeptide. Epithalamin is different: it is a peptide-extract preparation associated with pineal tissue, not a synonym for the sequence-defined compound. Names, identifiers, analytical results and experimental observations must not be transferred between the extract and the tetrapeptide.

The 2017 identification of AEDG within an analysed pineal polypeptide complex supplies historical context. It establishes neither equivalence with Epithalon nor any supplied batch identity.

The two registry numbers seen in catalogues also require separation. 307297-39-8 belongs to the defined AEDG tetrapeptide; the FDA record links it to UNII O65P17785G under the preferred substance name Epitalon. By contrast, 64082-79-7 traces to a historical NLM ChemIDplus deposit titled Epithalamin. Its later attachment to Epitalon entries is an old record merger or misassociation, not evidence that the two materials share identity.

A registry number alone does not resolve molecular form either. Epitalon acetate is separately registered as 307297-40-1. Accordingly, reliable matching starts with the full name and AEDG sequence, then checks formula, declared molecular form and batch-linked analytical documentation. No single catalogue field substitutes for that chain.

Historical identity source: Khavinson et al. 2017 · PMID 29124531

Supplied form, molecular form, storage conditions and stability information are pending reconciliation against label, specification and batch COA. No temperature, physical presentation or stability period is inferred from molecular literature. Sequence length alone establishes none of these properties.

For batch review, match the product name and AEDG sequence to the label and specification, then match the material's batch code to its COA. The certificate should identify the sample, analytical method, test date and result. An inconsistent link means it cannot be assumed to describe that material.

Any HPLC purity value is method- and batch-specific and cannot be generalised. HPLC alone does not necessarily establish sequence or molecular form; complementary identity evidence has a separate scope.

Laboratories intending to buy epithalon for controlled research in the EU should evaluate reference and batch identity separately. Papers define the investigated molecule, model, method and endpoint; released documentation defines supplied material. Neither substitutes for the other.

Epithalon is presented solely as research material for controlled laboratory work. The cited evidence consists of molecular, cell-culture, biological-material and bovine ex vivo research; it establishes no conclusion beyond those named systems and measurements.

Research use only. For laboratory research only. Not for human or veterinary use. Not intended to diagnose, treat, cure or prevent any disease. Not a medicinal product, food or cosmetic.