≥ 99 % · HPLC
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Melanotan 2
34,90 €
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≥ 99 % purity (HPLC)
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What is Melanotan 2
Melanotan 2 at a glance
Melanotan II (MT-II, MT2) is a synthetic, cyclic analogue of the natural peptide hormone alpha-MSH — a seven-amino-acid research compound that acts as a non-selective agonist at melanocortin receptors.
Its research record spans an early three-person human pilot study (1996), narrow controlled human experiments, rodent models and current receptor-pharmacology reviews. At Reborn Peptides, Melanotan II is strictly a research peptide, supplied lyophilised at 10 mg per vial.
Research overview
Receptor pharmacology: in studies, Melanotan II has been described as a non-selective melanocortin-receptor agonist (Wessells 2000); a 2024 review places melanocortin compounds within current GPCR tool-compound research (Weirath and Haskell-Luevano 2024).
Pigmentation and melanogenesis appear as measured research endpoints: an early phase-I pilot in three volunteers reported melanotropic and pigmentation measurements (Dorr 1996) — an extremely small design that cannot establish population outcomes.
Central melanocortin models: MT-II altered food-intake measurements across four preclinical hyperphagia models in rodents (Fan 1997, Nature). Behavioural and physiological measurements were examined in small human crossover experiments (Wessells 1998; 2000) and in female-rat models (Rössler 2006).
Context: the record consists of a tiny early pilot, narrow experiments, animal models and reviews. The endpoints belong to their models and must not be merged; Melanotan II is not an approved medicine.
Technical data
CAS number121062-08-6
SummenformelC₅₀H₆₉N₁₅O₉
Molekulargewicht1024,2 g/mol
SequenzAc-Nle-cyclo[Asp-His-D-Phe-Arg-Trp-Lys]-NH₂
Amino acids7
Purity≥ 99 % (HPLC)
PubChem CID92432
Target structuremelanocortin receptors (MC1R–MC5R)
Molekülstruktur
✓In vitro✓Animal modelHuman pilot4RCT5Approval
Non-selective melanocortin agonism
Small, early human record
Model-bound endpoints
Evidence
Research highlights
MT-II engages multiple melanocortin-receptor subtypes; exact pharmacology depends on receptor, species and assay.
Wessells 2000 · PMID 11035391 · Weirath 2024 · PMID 39296259
The human data consist of a three-person 1996 pilot and narrow crossover experiments — research documentation, not outcomes.
Dorr 1996 · PMID 8637402
Feeding, pigmentation and behavioural endpoints each belong to their own model and species; they must not be merged.
Fan 1997 · PMID 8990120
Research status
Referenced studies on Melanotan 2
4 selected sources — filterable by study type, each linked directly to its source.
Human pilotEvaluation of melanotan-II, a superpotent cyclic melanotropic peptide, in a pilot phase-I clinical study (n=3)Dorr RT et al., 1996, Life SciencesSource →Animal studyRole of melanocortinergic neurons in feeding and the agouti obesity syndrome (four hyperphagia models)Fan W et al., 1997, NatureSource →Human studyEffect of an alpha-melanocyte stimulating hormone analog on penile erection (small crossover, n=10)Wessells H et al., 2000, UrologySource →ReviewRecent advances in melanocortin receptor GPCR tool compoundsWeirath NA, Haskell-Luevano C, 2024, ACS Pharmacol Transl SciSource →
Research Deep Dive
The research in depth
Model-qualified findings in depth — every claim tied to a PubMed-indexed source.
7Amino acids, cyclic
MC1R–MC5RReceptor family
1996First human pilot
12PubMed sources
01Chemistry and molecular identity
Melanotan II is a synthetic, cyclic heptapeptide analogue of alpha-melanocyte-stimulating hormone (alpha-MSH). The cyclic lactam structure distinguishes it from linear alpha-MSH analogues such as Melanotan I — a structural lineage documented in the discovery literature of melanogenic peptides (Hadley et al. 1998; Hadley and Dorr 2006).
| Field | Specification |
|---|---|
| Substance name | Melanotan II (MT-II, MT2) |
| Substance class | Synthetic, cyclic alpha-MSH analogue (7 amino acids) |
| Receptor profile | Non-selective melanocortin-receptor agonist |
| CAS number | 121062-08-6 |
| Molecular formula | C₅₀H₆₉N₁₅O₉ |
| Molecular weight | 1024.2 g/mol |
| PubChem CID | 92432 |
| Regulatory status | Not an approved medicine |
| Intended use | Laboratory research only |
Sources: Hadley 1998 · PMID 9760697 · Hadley & Dorr 2006 · PMID 16412534
02Receptor pharmacology: a non-selective melanocortin agonist
In studies, Melanotan II has been described as a non-selective agonist at melanocortin receptors (Wessells 2000). Non-selective does not mean all receptor subtypes behave identically: the exact pharmacology depends on the receptor subtype, species and expression system of each assay — which is precisely what makes the compound useful as a defined tool in receptor research.
A 2024 review places melanocortin compounds, including MT-II, within current GPCR tool-compound research (Weirath and Haskell-Luevano 2024). Historically, the cyclic MT-II also sits at the origin of the PT-141 (bremelanotide) line — related research history, but chemically and documentarily separate substances.
Sources: Wessells 2000 · PMID 11035391 · Weirath 2024 · PMID 39296259
03Research landscape: pilot data, animal models, reviews
The findings below describe outcomes in controlled research settings. They do not establish an approved use, support self-experimentation or predict an outcome outside the cited studies — and the different endpoints must not be merged into one expected result.
Human pilot
Life Sciences, 1996 — phase-I pilot, three volunteers
Reported melanotropic and pigmentation measurements for the cyclic peptide in an early research setting; an extremely small design that cannot establish population outcomes.
Dorr et al. · PMID 8637402Animal model
Nature, 1997 — central melanocortin models
MT-II altered food-intake measurements across four preclinical hyperphagia models in rodents; antagonist comparison probed pathway involvement.
Fan et al. · PMID 8990120Human study
Urology, 1998/2000 — small crossover experiments
Physiological and self-reported endpoints measured versus placebo in crossover designs of around ten participants — narrow experimental records, not consumer outcomes.
Wessells et al. · PMID 11018622Animal model
Pharmacol. Biochem. Behav., 2006 — female-rat behavioural model
Altered proceptive-behaviour measurements in female rats; animal observations and human measurements remain separate evidence tiers.
Rössler et al. · PMID 17113634Review
ACS Pharmacol. Transl. Sci., 2024 — GPCR tool compounds
Synthesises the melanocortin tool-compound field and situates MT-II in current receptor research; a review orders prior work, it does not certify a batch.
Weirath & Haskell-Luevano · PMID 3929625904What the evidence does not establish
The record consists of a tiny early human pilot, narrow controlled experiments, animal models and reviews. It does not support merging pigmentation, feeding, receptor and behavioural endpoints into one expected result, and results from cell or animal models cannot be generalised to humans.
No publication verifies a commercial batch, its declared amount, form or analytical identity — that is what the batch COA is for. Melanotan II is not an approved medicine, and another compound's regulatory status implies nothing for MT-II.
05Format, storage and batch documentation
This Melanotan 2 research peptide is supplied as 10 mg of lyophilised powder per vial (SKU ML10). Lyophilised peptides are stored dry, protected from light and refrigerated; temperature cycling and moisture ingress are the practically relevant quality risks (Wang 2000; review of the stability and storage of lyophilised peptide preparations).
Batch documentation: Any purity statement is batch-specific and belongs to the applicable certificate of analysis, which connects batch number, test date, identity method (MS) and chromatographic result (HPLC). This page makes no blanket purity claim.
06Research supply for European laboratories
Reborn lists Melanotan 2 exclusively as a laboratory research material for laboratories and researchers across the EU. Twelve PubMed-indexed sources — from the 1996 pilot through the Nature feeding models to the 2024 tool-compound review — document the research landscape, and every scientific claim in this section is tied to one of them.
Research use only. For laboratory research only. Not for human or veterinary use. Not intended to diagnose, treat, cure or prevent any disease. Not a medicinal product, food or cosmetic.
FAQ
Frequently asked questions
What is Melanotan II?
A synthetic, cyclic analogue of alpha-MSH (7 amino acids) that acts as a non-selective agonist at melanocortin receptors.
Is MT2 the same as PT-141?
No. PT-141 (bremelanotide) is a separate substance derived from melanocortin research history; each compound carries its own literature and documentation.
How strong is the human evidence?
Very limited: a three-person pilot (1996) and small crossover experiments. These narrow records document research activity, not outcomes — most evidence is preclinical.
How does Reborn classify this product?
Strictly as a research peptide for laboratory use only, not for use in humans or animals. Every batch is documented with a certificate of analysis (COA), HPLC and MS.
How can I pay?
We accept prepayment by SEPA bank transfer as well as cryptocurrencies. All payments are processed securely and encrypted.
How fast and how is it shipped?
Discreet shipping from the EU within 4–5 business days. Neutral packaging with no reference to the contents.
